Spirometric Evaluation of Pulmonary Expiratory Flow Volume and Flow Rate in Patients with Clinical Hypothyroidism at a Tertiary Care Hospital, West Bengal, India: A Case-control Study

Introduction: Hypothyroidism is defined as a clinical condition caused by insufficient thyroid hormone secretion from the gland result of structural or functional defects in production. can impair respiratory function and cause ventilation problems. Spirometry used to assess pulmonary patients with disorders because low levels bronchial hyperactivity obstructive disease. Aim: To find out changes spirometric parameters hypothyroid compared apparently healthy individuals. Materials Methods: The study was case-control conducted Department Physiology Burdwan Medical College Hospital on 50 cases subjects. Inclusion criteria were diagnosed hypothyroidism, Body Mass Index (BMI) under 30 kg/ m2, age between 20 years. Serum TSH free T4 (FT4) measured Quantitative EIA method using RFCL- manufactured commercial “ELISCAN-TSH”-kitand“ELISCAN- Ft4”-kit. Forced Vital Capacity (FVC), Expiratory Volume 1 second (FEV1), FEV1/FVC, Flow (FEF) 25-75%, Peak Rate (PEFR) test tested RMS Helios 401 Spirometer. Pearson’s two-tailed correlation student independent-test done for analysis. Results: present showed that FEV1, FVC, PEFR FEF25%-75% significantly decreased hypothyroidism control. Mean values 85.30%, 92.42%, 90.70%, 74.86%, 75.63%, respectively which (p<0.001) Conclusion: This concluded causes significant function. Thus, proper knowledge respect this infection would help management these time.